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Careers at NCATS – NCBI

We are looking for innovative partners to join our dynamic team. Learn more about current job opportunities at NCATS.
Information provided by candidates will remain confidential and will not be released outside NCATS’ search process without signed consent from candidates.
Postdoctoral Positions in the Division of Preclinical Innovation
NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. NIH and HHS are Equal Opportunity Employers.
NIH is dedicated to building a diverse community in its training and employment programs.
Selected candidates for any fellowship opportunity described above are subject to a federal background check, using Standard Form-85 (read SF-85). Section 14 of the form asks, “In the last year, have you used, possessed, supplied, or manufactured illegal drugs?” The question refers to the illegal use of drugs or controlled substances in accordance with federal laws, even though allowed under state laws. Acceptance into all fellowship programs is conditional upon a successful background check.
Learn more about jobs at NIH.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Office of the Director           
Bethesda, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for the position of deputy director. The individual selected for this position will work closely with the center’s director to provide leadership in catalyzing the creation, demonstration and dissemination of innovative methods and technologies that enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. In addition to guidance and direction for the full NCATS portfolio, the selected individual will support the director in leading two critical translational science programs managed by NCATS — the Clinical Translational Science Awards (CTSA) Program and the Rare Diseases Clinical Research Network.
The deputy director will work collaboratively across NIH, throughout the federal government and with other key stakeholders and organizations to further the advancement of NCATS’ mission and objectives. He or she will serve as an ambassador and spokesperson for the center, communicating NCATS’ position and incorporating the views and needs of key stakeholders into NCATS’ plans and initiatives. The deputy director will facilitate the identification and development of future leaders through mentoring programs, continuous development of skills and expertise, and recognition of achievements. The deputy director will serve as a role model to the rest of the center, managing people and financial resources with integrity and fairness, while maintaining the center’s policies and priorities.
Applicants must possess an M.D. and/or Ph.D. or equivalent doctoral degree in the biomedical sciences or a relevant health-related field from an accredited educational institution, with broad senior-level research experience, experience in the direct administration of a research program, and expert scientific knowledge in the broad fields of biomedical, clinical and translational research. Applicants should be known and respected within their profession, both nationally and internationally, as distinguished individuals of outstanding scientific competence and administrative capability. Candidates should have demonstrated leadership abilities; the ability to serve as a spokesperson; and experience with planning, executing and assessing complex, multifaceted preclinical and clinical programs, particularly those using NIH extramural mechanisms. Experience also is required in resolving operational problems and issues, as well as managing financial and human resources, including building, motivating and maintaining a culturally diverse staff.
Salary is commensurate with qualifications and experience; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available. A recruitment or relocation bonus may be available, and relocation expenses may be paid.
Please read the guidance on Selective Service requirements.
Applicants who have completed part or all their education outside the United States must have their foreign education evaluated by an accredited organization to ensure that the foreign education is equivalent to education received in accredited educational institutions in the United States. We will accept only the completed foreign education evaluation. For more information on foreign education verification, visit the National Association of Credential Evaluation Services website. Verification must be received prior to the effective date of the appointment.
NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis.
Please submit (via email to Ms. Emily Ellis at SeniorRe@od.nih.gov) a current curriculum vitae with a complete bibliography, a narrative statement (one to two pages) that addresses the qualifications requirements, a narrative statement (one to two pages) that addresses how you envision supporting NCATS’ vision for advancing its translational science mission, and a narrative statement (one to two pages) indicating how you have promoted equity, diversity, inclusion and accessibility and describing your mentoring and outreach activities, especially those involving women; people with disabilities; and people from underrepresented groups, including racial and ethnic groups.
Applications must be received by 11:59 p.m. EDT on Sept. 25, 2023. Please direct questions regarding this position or the application process to Ms. Emily Ellis at 301-451-0086 or via SeniorRe@od.nih.gov.
Review of applications will begin Sept. 26, 2023, and will continue until the position is filled. Do not include your birthdate or social security number on application materials.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
The U.S. Department of Health and Human Services (HHS) protects the American people from health threats, researches emerging diseases and mobilizes public health programs with domestic and international partners. In support of this mission, HHS offers its employees the opportunity to volunteer to become federal civilian detailees and contribute their unique skills through voluntary temporary assignments to humanitarian emergencies or departmental priorities countering new and emerging health, safety and security threats.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for a scientific director (SD) position in the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. DPI encompasses all aspects of translational science, from target validation to first-in-human clinical studies. DPI has both technology development components and collaborative resource access programs covering small molecule and RNAi screening technologies and informatics, as well as translational efforts in biology; medicinal chemistry; pharmacokinetics; toxicology; absorption, distribution, metabolism, and excretion (ADME); and project management (see organization chart). The SD is responsible for an annual budget exceeding $94 million and a staff of approximately 325.
The SD serves as a key member of NCATS’ leadership team and works closely with the center director and heads of other NCATS divisions. The SD provides scientific and administrative leadership of DPI; oversees recruitment and professional development of staff; develops and implements new DPI initiatives; and catalyzes interactions among DPI’s research groups and between DPI and the other NCATS divisions, NIH institutes and centers, academic institutions, regulatory agencies, nonprofit and for-profit organizations, and the broader research and patient communities. The selected candidate will be responsible for creating and maintaining a nurturing research environment that encourages creativity, collaboration among scientists from different disciplines and organizations, effective training of students and postdoctoral fellows, and efficient use of resources. Finally, the SD serves as a frequent spokesperson for NCATS and translational research.
Applicants must possess a Ph.D. and/or M.D. or an equivalent doctoral degree and have an established record of outstanding research accomplishments, scientific leadership, mentorship and service within the basic and/or clinical scientific community. Candidates must have demonstrated experience in setting, planning, implementing and analyzing program objectives and priorities and demonstrated the ability to manage financial and human resources and coordinate a research portfolio that involves extensive internal and external collaborations. The selected candidate will be an innovative and strategic thinker, team player, and skilled communicator with strong interpersonal skills who can liaise and collaborate.
The SD may supervise their own research laboratory, supported by resources commensurate with the size and scope of their program.
Salary is commensurate with qualifications and experience and NIH salary guidelines. A recruitment or relocation incentive may be available, and relocation expenses may be paid. A full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Please see the following guidance regarding Selective Service requirements.
Selection for this position will be based solely on merit, with no discrimination for non-merit reasons, such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age or membership or nonmembership in an employee organization. NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities.
NIH inspires public confidence in our science by maintaining high ethical principles. NIH employees are subject to federal governmentwide regulations and statutes, as well as the agency-specific regulations described by this NIH Ethics Office fact sheet. We encourage applicants to review this information. The selected candidate will be required to complete a public financial disclosure report prior to the effective date of the appointment.
Applicants who have completed part or all of their education outside the United States must have their foreign education evaluated by an accredited organization to ensure that the foreign education is equivalent to education received in accredited educational institutions in the United States. We will only accept the completed foreign education evaluation. For more information on foreign education verification, visit the National Association of Credential Evaluation Services website. Verification must be received prior to the effective date of the appointment.
HHS protects the American people from health threats, researches emerging diseases and mobilizes public health programs with domestic and international partners. In support of this mission, HHS offers its employees the opportunity to volunteer to become federal civilian detailees and contribute their unique skills through voluntary temporary assignments to humanitarian emergencies or departmental priorities countering new and emerging health, safety and security threats.
NIH provides reasonable accommodations to applicants with disabilities. Please notify us if you require reasonable accommodation during any part of the application and hiring process. The decision to grant reasonable accommodations will be made on a case-by-case basis.
Interested individuals should apply by submitting (via email to NCATS-Applications@nih.gov) a cover letter, including a description of relevant research and administrative leadership experience; a curriculum vitae with a complete bibliography, including a description of mentoring and outreach activities; a vision statement for leading the DPI (not to exceed two pages) outlining your scientific vision or ideas for potential development of DPI programs; and a statement (not to exceed one page) addressing your commitment to diversity, equity, inclusion and accessibility (DEIA), including relevant examples of initiatives you have undertaken that illustrate your commitment to DEIA.
The review of applications will begin June 19, 2023, and will continue until the position is filled.
Incomplete or paper applications will not be evaluated. For more information about the position, contact Search Committee Chair Amy Newman, Ph.D., at anewman@intra.nida.nih.gov or emailNCATS-Applications@nih.gov.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health       
National Center for Advancing Translational Sciences       
Office of Administrative Management       
Administrative Services Branch       
Extramural Services Section       
Bethesda, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for a section chief position to manage the Extramural Services Section (ESS), part of the Administrative Services Branch (ASB), within the center’s Office of Administrative Management. The ESS (1) negotiates for and secures the resources and services needed to run the extramural offices/divisions and programs, including the Office of the Director; (2) provides technical, advisory, administrative and management support services, including procurement, budget, space planning, facility management, timekeeping, property management, travel management, human resources and administrative services; (3) serves as a primary advisor and assistant to senior leadership and staff in all phases of administrative management and; (4) develops, analyzes and implements new or modified administrative policies and procedures.
The selected candidate will manage and supervise a team of approximately 5 employees that performs a broad range of general administrative and related occupational tasks. The section chief will ensure that the work and support of subordinate administrative staff is effective, efficient, and that the overall delivery of services meets or exceeds the needs of the organizations serviced. The selected candidate will be responsible for coordinating administrative functions, solving problems, resolving complex issues, advising the program staff of policies and procedures, and providing a full range of administrative support services. They will develop special analyses and presentations to justify complex significant aspects of various administrative processes and policies. The section chief will communicate with senior leadership across the center, as well as with senior leadership throughout NIH, and serve on diverse committees and task groups within the center and across NIH, as appointed, based on personal competence, knowledge, expertise and experience in the administrative field. The extramural services section chief will maintain an awareness of activities in the administrative offices of other NIH institutes/centers, as they may affect NCATS activities. The section chief will report to the chief of the ASB, who reports to the center’s executive officer, a senior executive service- level position. The selected candidate will work closely with the chief of the ASB to establish standards and evaluation mechanisms for assuring high-quality business and administrative services to internal and external customers.
Applicants must possess knowledge and skill in analyzing administrative management issues and providing viable options and alternatives for implementation. Applicants must have experience in (1) planning and assigning work, (2) setting priorities and deadlines, (3) evaluating progress and outcomes, (4) establishing and clearly communicating guidelines and performance expectations, and (5) evaluating work performance of employees. The successful candidate also should possess strong oral and written communication skills, as well as excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner.
NCATS prioritizes an inclusive and team-centric culture; as such, the selected candidate will be expected to work closely with staff throughout the center, as well as with senior NCATS leaders and NIH management officials, on a wide range of issues that affect the organization. Therefore, in addition to being able to provide advice and instructions on technical and administrative issues, support staff training and development, and implement methods to improve quality and quantity of work efforts, the successful applicant should possess demonstrated experience in cultivating cooperative relationships and fostering a sense of organizational belonging among all employees.
Salary is commensurate with qualifications and experience and NIH salary guidelines. A full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Interested individuals should apply via USAJobs.gov Supervisory Administrative Officer announcement number NIH-NCATS-IMP-24-12183912 from November 2–6, 2023, for Montgomery County, Maryland. The announcement includes additional information regarding qualification requirements, evaluation criteria and application instructions.
Please direct questions about applying to Meghan Rudd at 301- 480-2654 or Meghan.Rudd@nih.gov.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.       
 
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Clinical Innovation           
CTSA Program Branch, Digital & Mobile Technologies Section           
Bethesda, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for a program officer (program director) position in the Digital & Mobile Technologies Section of the Clinical and Translational Science Award (CTSA) Program Branch within the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership abilities and demonstrated innovation and expertise in informatics, digital health and/or decentralized clinical research. The CTSA Program is an innovative national network of more than 60 medical research institutions that aims to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research. The Digital & Mobile Technologies Section helps to enable the broader development, implementation and dissemination of digital health and subsequent approaches for decentralized research resources and methods for the CTSA Program.
The program officer/program director (PO/PD) in the Digital & Mobile Technologies Section will oversee and manage CTSA Program cooperative agreements and grants throughout the award cycle. In collaboration with stakeholders within DCI and NCATS, across NIH institutes, centers and offices, and from other federal agencies, the PO/PD will support, develop and implement funding initiatives that address the focus areas of the CTSA Program. The PO/PD will serve as the DCI representative on the CTSA Program Enterprise Committees or Consortium Groups as well as represent NCATS on NIH-wide initiatives and interagency initiatives.
Each applicant should possess an advanced scientific health degree (M.D. and/or Ph.D.) and have extensive knowledge and experience in a relevant scientific discipline. Candidates must have (1) recognizable accomplishments and career progression in a research activity related to health or biomedical/behavioral sciences, as well as competence in management; (2) the ability to communicate effectively to plan, initiate, administer and evaluate a scientific program successfully; (3) familiarity with the dynamics of health-related research; (4) the ability to understand the internal relationships of partner and grantee organizations conducting research, as well as the practices and policies affecting national health research efforts; (5) the ability to work effectively and cooperatively with others; (6) experience developing and maintaining good working relationships with Initial Review Groups, members of National Advisory Councils and Boards, representatives of academic institutions, the scientific community, public and private organizations and agencies, and the general public, as well as supervisors, colleagues and subordinates.
The selected candidate must appreciate the challenges of working with diverse stakeholders and communicating impact clearly to various audiences. The selected candidate should be aware of new and emerging trends in clinical and translational science research and be able to communicate and collaborate well with others.
The current salary range is commensurate with experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) — 602 series — or Social Behavioral Scientist (101 series) at the GS 12/13/14 levels; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Interested individuals should submit applications via USAJobs.gov through the Health Science Administrator (601 series), the Physician (Research) — 602 series — or the Social Behavioral Scientist (101 series) at the GS 12/13/14 levels or be considered for a transfer within NIH if currently in these types of positions. This vacancy, open to all U.S. citizens, is advertised under delegated examining (DE) procedures under announcement NIH-GR-DE-23-11936070. This vacancy also is open under merit promotion (MP) procedures under announcement NIH-GR-MP-23-11935760. The USAjobs.gov announcements include additional information regarding medical and scientific specialties, qualification requirements, evaluation criteria and application instructions. Interested individuals also may submit a cover letter describing their interest in the position, current curriculum vitae and complete bibliography to Christopher M. Hartshorn, Ph.D., chief, Digital & Mobile Technologies Section, CTSA Program Branch, Division of Clinical Innovation, via christopher.hartshorn@nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Clinical Innovation           
Clinical Affairs Branch           
Bethesda, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for a Trial Innovation Network section chief position in the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership and demonstrated expertise in improving clinical trial efficiency through tool development, clinical trial training and education. The selected candidate also will be expected to broaden the scope of clinical trial questions and the clinical trial enterprise so that trials address the health concerns of people in a broad variety of situations and locations, including those living in rural and remote locations, individuals of diverse cultures and beliefs, and minority populations.
The section chief will be responsible for developing a strategy to test, disseminate and incorporate the tools developed by this section and from other parts of the NCATS Trial Innovation Network, ensuring the dissemination and sustainability of these tools within NCATS-funded programs, NIH and the extramural research community. Dissemination should include a variety of organization types and geographic locations. To facilitate this, the Trial Innovation Network section chief will work with clinical trial networks and training programs through NIH and non-NIH programs to ensure that the tools are accessible and used appropriately. This process will be iterative and bilateral, such that suggestions and requests from collaborators will be provided back to the Trial Innovation Network to make sure the needs of participants, families, communities, providers and researchers are optimized. To this end, community engagement will be important to enhance the tool development process, increase uptake and dissemination, and ensure that the necessary types of tools are developed.
Clinical trials are balanced by understanding efficacy/effectiveness and outcome measures, but safety is paramount. Therefore, the section chief will be responsible for tool development that highlights, flags or streamlines safety issues and will lead clinical safety protocol activities within DCI. The position will be within the Clinical Affairs Branch of DCI, which supports the NCATS Trial Innovation Network and The Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®
The Trial Innovation Network section chief will be responsible for providing authoritative, technical and scientific leadership and guidance for the clinical trial activities within DCI and when needed by NCATS and NIH. The section chief will direct the activities of the section, including providing a national resource for rapid response to public health emergencies via the Trial Innovation Network and promoting the identification, development and dissemination of innovative clinical trial designs and recruitment strategies. The section chief will develop and provide resources for the planning, implementation and conduct of NIH-supported clinical trials. The section’s products and resources aim to improve clinical trial efficiency, maximize safety and enhance the types of information within clinical trials. Examples of the activities within the section will include the implementation of techniques/tools to enhance trial design, site selection efficiency, Institutional Review Board efficiency, startup and expansion efficiency, realistic cost, and time calculations for both NIH and investigator expectations, personnel, and site turnover issues.
The section chief will serve as a senior leader, representing DCI and NCATS in clinical, research and clinical trial training/career development programs across NIH, other government agencies, industry, academia and patient-support organizations. The section chief will provide advice to the clinical affairs branch chief and the DCI director on trial-, safety- and clinical-related matters. The section chief will also work to diversify the clinical trial landscape by working in coordination with the various components of DCI, including the Education and Training Section of the Clinical and Translational Science Awards (CTSA) Program Branch. The CTSA Program Branch supports the CTSA Program, an innovative national network of more than 60 medical research centers that aims to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research.
The successful candidate will have a Medical Doctorate (M.D.), an active state medical license, and real-world experience in academia or industry in clinical trial development and conduct. The successful candidate will have experience in trial bottlenecks/barriers, optimization strategies and potential efficiencies. An important aspect of the position will be safety; therefore, the successful candidate will have extensive experience with clinical safety issues. The successful candidate also will have strong and demonstratable experience in conceiving, developing and testing tools to support clinical trials in novel groups and settings. The successful candidate will also have a strong history of working with diverse federal and nonfederal organizations and partners.
The successful candidate must have extensive experience in (1) leading a diverse, highly complex research program and employing strategies for implementing and disseminating research tools and products; (2) providing expert advice to senior leaders on scientific and clinically relevant policies and programs; (3) developing innovative training programs for advancing clinical tool development, dissemination and usage by trainees; and (4) leading teams. The successful candidate must appreciate new trends in the clinical trial enterprise, such as the novel use of informatics, big data and site-selection strategies to improve the conduct of trials. The successful candidate will have the ability to communicate and collaborate well with others.
Candidates should demonstrate (1) a clear pattern of success in setting, planning, implementing and analyzing research projects, program objectives and priorities; (2) the ability to communicate and collaborate effectively with diverse scientific and lay audiences; and (3) the ability to form collaborations with national and international organizations, as well as with individuals who represent wide-ranging disciplines and competing priorities.
Salary is commensurate with qualifications, experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Interested individuals should apply from May 24 to June 23, 2023 (submission deadline may be extended if needed) by submitting (via email) a cover letter describing their interest in the position and a curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to NCATSSBRBPASPosition@nih.gov. Include your name and name of the position in the subject line. Please submit questions about this position to Salina Waddy, M.D., via salina.waddy@nih.gov. Review of applications will begin June 24, 2023, and will continue until the position is filled. Do not include your birthdate or social security number on application materials.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Clinical Innovation           
CTSA Clinical Affairs Branch, Trial Innovation Network Section           
Bethesda, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for a program officer (program director) position in the Clinical Affairs Branch, Trial Innovation Network (TIN) Section within the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership abilities and demonstrated expertise in improving clinical trial efficiency through tool development, regulatory science in clinical trials, health disparities/equity trials, community engagement, and clinical trial training and education. The selected candidate also will be expected to broaden the scope of clinical trial questions and the clinical trial enterprise so that trials address the health concerns of people in a broad variety of situations and locations, including those living in rural and remote locations, individuals of diverse cultures and beliefs, and minority populations.
The TIN develops trial efficiency tools to test, disseminate and incorporate the tools developed by this section and other parts of the NCATS TIN, ensuring the dissemination and sustainability of these tools within NCATS-funded programs, the Clinical and Translational Science Awards (CTSA) Program, NIH and the extramural research community. To facilitate this, the TIN program officer (program director) will work with clinical trial networks and training programs through NIH and non-NIH programs to ensure the tools are accessible and used appropriately. This process will be iterative and bilateral, so suggestions and requests from collaborators will be provided back to the TIN to ensure the needs of participants, families, communities, providers and researchers are optimized. To this end, community engagement will be essential to enhance the tool development process, increase uptake and dissemination and ensure that the necessary tools are developed. The TIN also supports the Helping to End Addiction Long-term® Initiative or NIH HEAL Initiative®.
The program officer (program director) will be responsible for project and network activities and coordinating a toolkit for investigators to use TIN tools. The section’s products and resources aim to improve clinical trial efficiency, maximize safety and enhance the types of information within clinical trials. Examples of the activities within the section will include implementing techniques and tools to enhance trial design, site selection efficiency, Institutional Review Board efficiency, startup, and expansion efficiency, for both NIH and investigator expectations, personnel and site turnover issues. The program officer (program director) will manage cooperative agreements and programs within the TIN and develop trial-related initiatives to improve the efficiency of the clinical trial enterprise and work with TIN investigators on trial-related workgroups.
Each applicant should possess an advanced scientific health degree (M.D. and/or Ph.D.) and have extensive knowledge and experience in clinical research and knowledge of regulatory science related to clinical trials. Candidates must have (1) recognizable accomplishments and career progression in a research activity related to health or biomedical/behavioral sciences, as well as competence in program management with extensive experience as a program director; (2) the ability to communicate effectively to plan, initiate, administer and evaluate a scientific program successfully; (3) knowledge in the dynamics of health-related research including regulatory science; (4) the ability to understand the internal relationships of partner and grantee organizations conducting research, as well as the practices and policies affecting national health research efforts; (5) the ability to work effectively and cooperatively with others; (6) experience developing and maintaining good working relationships with review groups, members of national advisory councils and boards, representatives of academic institutions, the scientific community, public and private organizations and agencies, and the general public, as well as supervisors, colleagues and subordinates.           

The selected candidate must appreciate the challenges of working with diverse stakeholders and communicating impact clearly to various audiences. The selected candidate should be aware of new and emerging trends in clinical and translational science research and be able to communicate and collaborate well with others.
The current salary range is commensurate with experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) — 602 series — or Social Behavioral Scientist (101 series) at the GS 14 level; a full civil service package of benefits — including retirement; health, life, and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Interested individuals should submit applications via USAJobs.gov through the Health Science Administrator (601 series), the Physician (Research) — 602 series — or the Social Behavioral Scientist (101 series) at the GS 14 level or be considered for a transfer within NIH if currently in these types of positions.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).           

At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutics Development Branch           
Medicinal Chemistry Group           
Rockville, Maryland
NCATS, a major research component of the NIH, seeks applications from exceptional candidates to fill a senior medicinal chemist (staff scientist) position in the Therapeutic Development Branch (TDB) within its Division of Preclinical Innovation (DPI) in Rockville, Maryland. The selected applicant will manage Investigational New Drug–enabling drug development projects involving collaborations with other NIH institutes, centers and offices; academic scientists; and industry and nonprofit organizations.
The scientists within DPI come from a broad range of scientific disciplines — including therapeutic discovery, medicinal chemistry, pharmacology and preclinical development — and work to reduce, remove or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce. This position will require a strong understanding of all aspects of medicinal chemistry and related disciplines to be able to advance projects from lead identification to the development of candidate selection. The senior medicinal chemist will work with project teams to define project goals and go/no-go criteria and manage timelines and chemistry resources to drive projects toward key decision criteria.
The selected candidate will lead projects at various stages, from lead generation through clinical candidate nomination, and will be responsible for designing, implementing and executing synthetic and medicinal chemistry strategies; developing new technologies to accelerate drug discovery; presenting results in internal and external meetings; and writing reports and manuscripts. Research will be conducted in the TDB medicinal chemistry group.
Applicants should possess a doctoral degree (M.D., Ph.D. or equivalent) in organic chemistry or medicinal chemistry, with at least 10 years of experience working in drug discovery or related fields. A strong background in synthetic organic chemistry is required. Experience in synthesis of complex small molecules, including natural products and designer molecules, is highly desirable. Candidates with experience in developing new methods or technologies highly relevant to the broad field of drug development will be considered favorably. Applicants should be able to lead medicinal chemistry projects and have a strong track record of scientific innovation and success in delivering clinical candidates. The ideal applicant should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. The applicant should possess strong oral and written communication skills, with a proven publication record in peer-reviewed journals.
Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Please submit a cover letter describing your interest in the position, including a career synopsis (one to three pages); a current curriculum vitae and complete bibliography; and the names of and contact information for three references to Wenwei Huang, Ph.D., via ncatsssrecruit@mail.nih.gov. The position will remain open for 30 days beginning April 7, 2023. To learn more about the Therapeutics for Rare and Neglected Diseases (TRND) program, visit https://ncats.nih.gov/trnd.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Clinical Innovation           
CTSA Program Branch, Education and Training Section           
Bethesda, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates for a program officer (program director) position in the Education and Training Section of the Clinical and Translational Science Award (CTSA) Program Branch within the center’s Division of Clinical Innovation (DCI). Candidates should have recognized leadership abilities and demonstrated innovation and expertise in clinical research. The CTSA Program is an innovative national network of more than 60 medical research institutions that aims to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research. The Education and Training Section plans, conducts and supports the CTSA Education and Training Program in training and cultivating the translational science workforce and fostering the development of the field of translational science.
The program officer in the Education and Training Section will support extramural grants through the CTSA Program, with a focus on institutional training, institutional career development, research education, small research grants and supplement awards (including research supplements to promote diversity, re-entry and reintegration into health-related research careers). Program officers in this section serve as DCI representatives to the CTSA Program groups focused on supporting the clinical and translational science workforce, including the Workforce Enterprise Committee, KL2 principal investigator (PI)/program director (PD) Group, and TL1 PI/PD Group.
Each applicant should possess an advanced scientific health degree (M.D. and/or Ph.D.) and have extensive knowledge and experience in a relevant scientific discipline. Candidates must have (1) recognizable accomplishments and career progression in a research activity related to health or biomedical/behavioral sciences, as well as competence in management; (2) the ability to communicate effectively to plan, initiate, administer and evaluate a scientific program successfully; (3) familiarity with the dynamics of health-related research; (4) the ability to understand the internal relationships of partner and grantee organizations conducting research, as well as the practices and policies affecting national health research efforts; (5) the ability to work effectively and cooperatively with others; (6) experience developing and maintaining good working relationships with Initial Review Groups, members of National Advisory Councils and Boards, representatives of academic institutions, the scientific community, public and private organizations and agencies, and the general public, as well as supervisors, colleagues and subordinates.
The selected candidate must appreciate the challenges of working with diverse stakeholders and communicating impact clearly to various audiences. He or she should be aware of new and emerging trends in clinical and translational science research and be able to communicate and collaborate well with others.
The current salary range is commensurate with experience and accomplishments for a Health Science Administrator (601 series), Physician (Research) — 602 series — or Social Behavioral Scientist (101 series) at the GS 12/13/14 levels; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Interested individuals should submit applications via USAJobs.gov through the Health Science Administrator (601 series), the Physician (Research) — 602 series — or the Social Behavioral Scientist (101 series) at the GS 12/13/14 levels or be considered for a transfer within NIH if currently in these types of positions. This vacancy, open to all U.S. citizens, is advertised under delegated examining (DE) procedures under announcement NIH-GR-DE-23-11936070. This vacancy also is open under merit promotion (MP) procedures under announcement NIH-GR-MP-23-11935760. The USAjobs.gov announcements include additional information regarding medical and scientific specialties, qualification requirements, evaluation criteria and application instructions. Interested individuals also may submit a cover letter describing their interest in the position, current curriculum vitae and complete bibliography to Patrick H. Brown, Ph.D., section chief, CTSA Program Branch, Education and Training Section, Division of Clinical Innovation, at patrick.brown@nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Informatics Core           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a staff scientist (informatics algorithms engineer) position in the Informatics Core (IFX) within the Division of Preclinical Innovation (DPI).
The mission of IFX is to produce data-driven decisions and accelerate translation through innovative informatics methods and software and deep domain expertise in informatics and various translational research data types. This mission is achieved through our team science culture and collaborations that span DPI, extramural NCATS programs, other federal institutions, industry/biotech, and academic institutions nationally and internationally.
IFX efforts and contributions are broadly organized into (1) Building Standards, Knowledge Sources, and Software; (2) Translational Data Analytics; (3) Scientific Computing Services and Research. These efforts are highly synergistic where outcomes from one category inform and are expanded into others.
The successful candidate will develop novel informatics and statistical methods/workflows and proof-of-concept tools to support the integration, analysis and interpretation of translational research data and make these outcomes publicly available to the broader research community. These data result from efforts in basic research, patient-oriented research and population-based research. The selected candidate will interact closely with the IFX director, computational and noncomputational (e.g., biologists, chemists, clinicians) IFX and NCATS scientists and our academic collaborators. He or she will contribute to the strategic vision and to the mentoring of trainees. The selected candidate will be encouraged to seek NCATS, NIH or external collaborations to further amplify and improve the center’s IFX informatics methods and software. He or she will elaborate on machine and deep learning and architectures from aggregation and cleaning of in-house translational research data (e.g., high-throughput screens, multi-omic, knowledge sources on chemical, biological, or disease annotations, etc.). To augment translational research efforts, the selected candidate will promote the use of and/or contribute to the development of chemical, biological and disease standards that help piece together complementary lines of information.           

The selected candidate will be expected to create and maintain documentation for methods/workflows to enable their reuse by IFX members or other researchers. Furthermore, he or she will contribute to the establishment of software development and deployment best practices for IFX, including acting as an owner/point of contact for repositories, data systems and servers. The selected candidate will contribute to building a consolidated scientific computing environment through integration and interoperability of libraries and software and will apply or develop appropriate, state-of-the art methods to support large-scale data-acquisition efforts within the DPI. Active participation in IFX and NCATS committees and meetings, as appropriate, will be encouraged to showcase and obtain feedback (e.g., user feedback) on methods and software developed. He or she will be expected to draft manuscripts and publish results in high-impact, peer-reviewed scientific journals and to present results at internal and external scientific meetings.
The ideal candidate should possess a doctoral degree (M.D., Ph.D. or equivalent) in a relevant field and be a recognized expert in the field. Applicants should possess a broad range of informatics experience that includes at least some of the following: Machine learning and/or deep learning (Bayesian inference, Probabilistic programming, NLP, TensorFlow, etc.); experience in graph, NoSQL and/or RDBMS databases and semantic data standards (e.g., OWL, RDF); scripting programming for high-throughput data processing and visualization (e.g., R, Python); Linux environments, high-computing servers, cloud computing; versioning systems (GitHub), full-stack software development. A strong preference will be given to applicants with knowledge in biology and/or chemistry and an understanding of data provenance (e.g., cell biology, methods for measuring multi-omic data, high throughput screens, biochemistry, genetics). Candidates should have proven experience in analyzing a broad range of data types across different diseases and exploit these data for therapeutic development. The selected candidate should have excellent interpersonal, verbal and written communication skills and should possess excellent analytical, organizational and time management skills. The desire and drive to seek out and master novel technologies and to develop new ones is expected.
Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.           

The review of applications will begin immediately and will continue until the position is filled. Learn more about informatics research at NCATS.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Chemical Technologies Group           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research associate (biology) position in the Chemical Technology group within its Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal and process chemists, and computational scientists who work on a broad portfolio of preclinical drug discovery projects, as well as programs that involve the development of innovative new technologies to enable the acceleration of biomedical research. The Chemical Technology group operates at the interface between chemistry and biology. A major focus of the team involves conducting large-scale chemogenomic screenings to identify novel targets and to develop novel strategies for therapeutic intervention, mostly focusing on oncologic indications. A second major focus of the team involves the discovery, optimization and advancement of novel biologically active small molecules.
The selected candidate will maintain mammalian cell-line cultures and expand them to scale in preparation of high-throughput drug screening; prepare various media, stock supplies and other reagents for use in the laboratory; perform in vitro cell-based assays to support the molecular characterization of drugs’ mechanism of action. These include DNA/RNA extraction, PCR and western-blot. The selected applicant also will maintain accurate daily records of experiments and results and interpret, evaluate and discuss the result of each experiment as part of the experimental-planning process. The selected candidate will perform computer analysis of data and use various software to prepare data figures for both internal discussion and publication.
Applicants to this research associate (biology) position should possess a bachelor’s degree in biology, biochemistry or other related life science discipline. A master’s in cell biology, immunology, biochemistry or other related life science discipline is preferred. The selected candidate should possess a conceptual understanding of cancer biology and knowledge of major oncogenic signaling pathways in human cancers, a strong background in cell biology, have at least two years of previous experience with standard molecular biology techniques (e.g., tissue culture, RNA and DNA extraction, PCR and western-blot) and be proficient at the bench. He or she should demonstrate attention to detail and possess strong organizational and interpersonal skills. Applicants also should possess excellent verbal and written communication skills, the ability to interpret, summarize and present scientific results in a clear, concise and accurate manner; and be able to work productively as a member of a diverse and dynamic multidisciplinary team.
The ideal candidate will have previous experience with high-throughput drug screening, Illumina next-generation sequencing platforms and related library preparation procedures (especially RNA-Seq and single-cell analysis), as well as documented knowledge of the hippo signaling pathway. Previous experience in microscopy, immunocytochemistry and flow cytometry, as well as strong computer literacy and Microsoft Excel proficiency — particularly with respect to graph/plots generation and analysis of large data sets — will be considered a plus.
Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to ncatspt3hiring@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
3-D Tissue Bioprinting Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a research scientist (virology) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation.
The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge technologies — including tissue biofabrication, tissue chips, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies (e.g., scRNAseq) — to develop advanced 3-D cellular models to study viral infections and drug screening. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. The selected candidate also will be expected to work independently as a well-trained problem solver in virology. Effective communication and presentation skills are required. The selected applicant will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The selected candidate will draft technical reports, manuscripts and patent applications, and present work to internal and external collaborators as needed. The selected candidate also should be eligible to work in the U.S. with whomever NCATS collaborates worldwide.
Applicants to this research scientist position should possess a Ph.D. in virology, cell or molecular biology or pharmacology, and at least three years of postdoctoral experience. The selected candidate should have expertise in virology to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and drug testing. Applicants should have additional expertise in histology, fluorescence microscopy, flow cytometry, single-cell RNA sequencing (scRNAseq), and production of induced pluripotent stem cell-derived cells. Candidates with previous experience working in a BSL3 lab and in areas such as organoids, tissue chip, cell imaging, histology and engineering of cells with biosensors will be considered favorably.
Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Chemical Genomics Branch           
Stem Cell Translation Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a bioinformatician position in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as induced pluripotent stem cells, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems.
The successful candidate will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS and collaborators at top academic institutions.
Computational analysis is integral to the laboratory’s efforts in the deep characterization of stem cell states and functional cell types from different developmental lineages. The bioinformatician will be required to promptly turn around analysis results to respond to biologists’ ongoing projects, work on multiple projects in parallel, and coordinate and oversee data analysis with external service providers.
Applicants should have a master’s degree or higher in bioinformatics, computational biology or biomedical data science. The ideal candidate should have strong science communication skills; clear and effective data visualization skills; the ability to work well independently and in a team environment; creative problem-solving skills; and a proven ability to apply the cutting-edge, rigorous standards of the bioinformatics fields. Applicants should possess a solid knowledge of R statistical programming language; familiarity with the handling, management and storage of large-scale sequencing data; and experience querying public databases, including the SRA, GEO and dbGaP.
Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms (e.g., bulk and single-cell RNA-Seq; ChIP-seq methods, such as MeDIP-seq; bulk and single-cell ATAC-seq; and miRNA-seq). Experience with other ‑omics — such as WES, WGS and targeted sequencing methods — are a plus. The ideal candidate will have experience with preprocessing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, HTSeq, featureCounts, salmon, GATK) and R packages designed for the above-mentioned methods (e.g., DESeq2, limma, Seurat). A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of NIH’s high-performance computing capabilities, are preferred.
Salary is commensurate with experience and accomplishments; a full civil service package of benefits — including retirement; health, life and long-term care insurance; and Thrift Savings Plan (401[k] equivalent) participation — is available.
Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
The Division of Preclinical Innovation (DPI) is the intramural (i.e., on-site) research program of NCATS and is located in Rockville, Maryland, a few miles from the main NIH campus in Bethesda, Maryland. DPI focuses on early stages of the translational process, from target validation to first-in-human studies. More than 200 scientists from a variety of disciplines and across the spectrum from early-career scientists to senior leaders are responsible for advancing the diverse research portfolio of DPI. In addition to conducting cutting-edge laboratory research, DPI scientists collaborate with more than 250 research organizations worldwide.
DPI scientists work in a collaborative, team-based environment. The postdoctoral candidate will be recruited to work on the specific projects described below and will have ample opportunities to collaborate with scientists both within and outside of NCATS on additional projects. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Postdoctoral fellows also gain additional professional skills and exposure to a variety of career paths through participation in the DPI training program.
National Institutes of Health    
National Center for Advancing Translational Sciences    
Division of Preclinical Innovation    
Early Translation Branch    
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a biology postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.
The selected postdoctoral fellow will work under the mentorship of Sarine Markossian, Ph.D. Markossian leads the Assay Guidance Manual (AGM) program in an interactive laboratory environment within ETB. The successful candidate will use cutting-edge cell biology and bioassay technologies to establish a research program centered around best practices in early drug discovery, including the successful development of robust, early-stage drug discovery assays. The fellow will be involved in all aspects of implementing small-molecule screening programs—including assay design, assay development and optimization, high-throughput screening, and data analysis—to address long-standing and emerging challenges and bottlenecks in preclinical translational science, such as increasing assay robustness and reproducibility, and addressing assay artifacts and interferences, and to establish best practices for preclinical research. The fellow also will be able to participate and engage in any AGM-related activities outside the bench and potentially gain experience in eBook editing, education-related activities, scientific workshop organization and program management.
The AGM program is NCATS’ unique translational science initiative that aims to help bridge the gap between research discoveries and the delivery of new therapies by creating and disseminating best laboratory practices, tools for data analysis and standards for rigor in preclinical drug discovery. More information on this program can be found in a recent article (The NCATS Assay Guidance Manual Programme: Advancing the Practice and Rigour of Preclinical Translation) published in Nature Reviews Drug Discovery.
The postdoctoral fellow will work on projects that involve leveraging existing data sets to derive insight into best practices in probe development, high-throughput screening methodologies, and robust assay development, as well as provide practical advice and lessons learned to the community related to these topics. The fellow also will conduct laboratory-based research—such as high-throughput screens—to profile libraries, assays and cells. This research will help identify and raise awareness around common pitfalls in preclinical research, as well as provide best practices to avoid such pitfalls, thereby eliminating bottlenecks in the process.
The selected candidate should have a background in biochemistry, molecular biology, cellular biology or a related discipline. Informatics experience is preferred but not required, and experience with drug screening is useful but not mandatory. Prior high-throughput screening experience is not a prerequisite. The fellow will learn to work in a team-based world-class drug discovery environment. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The selected candidate also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.
Applicants should have (or expect to receive) a Ph.D. and have fewer than 3 years of postdoctoral experience in cell biology, molecular biology, biochemistry or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply. The selected candidate should be an independent thinker and team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Sarine Markossian, Ph.D., at sarine.markossian@nih.gov. Applicants also should indicate when they are available to start.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch                    
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (computational biologist/bioinformatician) position in the Biology Group of the Therapeutic Development Branch (TDB) within the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. DPI routinely partners with external collaborators from universities, pharmaceutical and biotechnology companies, and disease research foundations to form multidisciplinary project teams with expertise in assay development, high-throughput screening, bioinformatics analysis, medicinal chemistry, disease-relevant biological models and preclinical drug development. As such, the TDB Biology Group is looking for a self-motivated postdoctoral fellow to work in a highly creative and collaborative team environment — with a focus on bioinformatics and -omics data analysis — to advance drug discovery and drug development projects.
Research conducted by members of the TDB Biology Group has a broad focus and spans multiple disease areas, including genetic diseases (e.g., lysosomal storage disorders, neuronal diseases, cancer) and infectious diseases. The team is applying patient-derived induced pluripotent stem cell (iPSC) disease models, including 2-D cells and 3-D organoids, to study disease pathophysiology and evaluate drug efficacy.
The selected candidate will learn and apply advanced computational techniques and methods for translational research. The fellow will perform bioinformatic analysis of the compound screening data and -omics profiling data, including RNAseq and proteomics data. The fellow also will have the opportunity to develop and employ AI-based models for virtual compound screening, as well as AI-based modeling for biomarker development. They will learn and participate in the drug development process and will collaborate with researchers from other NIH institutes and centers, as well as with academic institutions with which NCATS collaborates. The selected candidate will present experimental findings at scientific conferences. Upon completion of training, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities.
The fellow will communicate results to project team members and collaborators and provide updates to senior management. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The fellow also will write technical reports and manuscripts.
The ideal candidate should possess a doctoral degree (Ph.D.) with a background in biology, computer science, bioinformatics or a related discipline. Previous experience in -omics data analysis, AI-based computational modeling/virtual screening, and/or compound screening data analysis is preferred. The candidate should have a strong record of publishing research results in high-impact, peer-reviewed scientific journals. Applicants should be independent thinkers and team players who are able to work in an interactive and fast-paced environment. The selected candidate is expected to present results of ongoing work at meetings (e.g., internal group meetings, project team meetings, national conferences) and submit their work for publication in peer-reviewed scientific journals. Therefore, effective communication and presentation skills are required. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email PDF versions of (1) a cover letter that includes a research summary and describes your interest in the position and (2) a current curriculum vitae with a complete bibliography, as well as contact information for two or three references, including your current supervisor, to Catherine Chen, Ph.D., at catherine.chen@nih.gov.
The review of applications will begin immediately and will continue until the position is filled
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch           
Biology Group           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (biologist) position in the Biology Group of the Therapeutic Development Branch (TDB) within the center’s Division of Preclinical Innovation (DPI) in Rockville, Maryland. DPI routinely partners with external collaborators from universities, pharmaceutical and biotechnology companies, and disease research foundations to form multidisciplinary project teams with expertise in assay development, high-throughput screening (HTS), bioinformatics analysis, medicinal chemistry, disease-relevant biological models and preclinical drug development. As such, the TDB Biology Group is looking for self-motivated postdoctoral fellow to work in a highly creative and collaborative team environment to advance drug discovery and drug development projects.
Research conducted by members of the TDB Biology Group has a broad focus and spans multiple disease areas, including genetic diseases (e.g., lysosomal storage disorders, neuronal diseases, cancer and infectious diseases).
The selected candidate will develop in vitro biochemical and cell-based assays for HTS of compound libraries to identify lead compounds, which will be used as tools to further understand disease pathophysiology and to be developed as therapeutics. They will learn and participate in the drug development process and will apply new technologies such as patient-induced pluripotent stem cell (iPSC)-based disease modeling and 3-D organoids for evaluation of drug efficacy and toxicity. The fellow will collaborate with researchers from other universities and NIH institutes and centers, and he or she will present experimental findings at scientific conferences. Upon completion of orientation and training, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities.
The fellow will communicate results to project team members and collaborators and provide updates to senior management. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The fellow also will write technical reports and manuscripts.
The ideal candidate should possess a doctoral degree (Ph.D.) with a background in cell biology, molecular biology or pharmacology, and have a strong record of publishing research results in high-impact, peer-reviewed scientific journals. Experience in human iPSC-related research or drug screening is preferred, although training in these areas will be provided. Applicants should be independent thinkers and team players who are able to work in an interactive and fast-paced environment. Candidates are expected to present results of ongoing work at meetings (e.g., internal group meetings, project team meetings and national conferences) and submit their work for publication in peer-reviewed scientific journals. Therefore, effective communication and presentation skills are required. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email (in PDF format) a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for two to three references, including your current supervisor, to Catherine Chen, Ph.D., at catherine.chen@nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch           
Molecular Modeling and Informatics Group           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral (molecular modeling, bioinformatics) fellow position in the Therapeutic Development Branch (TDB) as a member of the Molecular Modeling and Informatics Group (TDB-MMI) within the Division of Preclinical Innovation.
The mission of TDB-MMI is to use computational approaches to help TDB project teams get drugs for rare diseases to the clinic as quickly as possible. TDB-MMI efforts include design and implementation of methods in bioinformatics, chemoinformatics, statistics, data infrastructure, molecular modeling and computational chemistry. TDB-MMI is an intensely collaborative group that currently works with more than 50 scientists within and outside of NIH.
The selected candidate will provide computational support for TDB drug discovery as part of TDB-MMI’s mission to support projects in the TDB portfolio. He or she will develop computational methods to predict cancer oncogenes and drug targets and, based on these, propose synergistic drug combinations for testing in cell-based and animal models of cancer. This effort is part of a TDB comparative oncology project, the goal of which is to find better ways to use animal models to best recapitulate human disease. The selected candidate also will develop a rare disease data system that will enable users to upload their laboratory’s rare disease data, connect it to publicly available data and run queries across the connected data to obtain insights that facilitate drug discovery. This effort is part of TDB’s RareSource project, the goal of which is to create a comprehensive data system for scientists to use in their rare disease research.
The ideal candidate should possess a Ph.D. in a computation-related discipline (i.e., computer science, database design, bioinformatics, cheminformatics, biostatistics or computational chemistry/physics). In addition, the ideal candidate should possess a general knowledge of drug discovery and the desire to learn additional techniques as necessary. Applicants should have completed one to three years of research and have proven experience — exhibited by first-author publications — in any of the computation-related areas described above. The selected candidate should have excellent interpersonal, verbal and written communication skills in English; be able to work well as a member of an interdisciplinary team; and possess excellent analytical, organizational and time management skills. TDB-MMI will only consider applicants who are U.S. citizens or legal residents who hold valid work permits.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Gregory J. Tawa, Ph.D., at gregory.tawa@nih.gov.           

The review of applications will begin immediately and will continue until the position is filled. Learn more about informatics research at NCATS.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Drug Metabolism and Pharmacokinetics Core           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional scientists for a postdoctoral fellow position in physiologically based pharmacokinetic (PBPK) modeling — for preclinical development projects involving drug metabolism and pharmacokinetics (DMPK) — within the center’s Division of Preclinical Innovation.
The DMPK Core partners with academic institutions, foundations and private industry to conduct preclinical discovery and development studies leading to Investigational New Drug (IND) applications for new therapeutics. These projects play a leading role in NCATS’ mission to develop new ways to reduce, remove or bypass bottlenecks across the continuum of translational science and address rare and neglected diseases.
The selected candidate will collaborate with team members to conduct in vitro absorption, distribution, metabolism and elimination (ADME) and in vivo pharmacokinetic (PK) studies and develop PBPK models for assigned projects. Specific duties include independently performing in vitro ADME testing, conducting in vivo PK studies in laboratory animals, and developing PBPK models for NCATS drug development projects. These PBPK models will be used to guide the selection of lead drug candidates and predict human PK profiles prior to the clinical trials. The selected candidate will disseminate their research by publishing results in peer-reviewed journals and participating in scientific conferences and meetings.
Applicants to this postdoctoral fellow position should hold a Ph.D. in pharmaceutical science, pharmacology, pharmacokinetics or computer science — with a focus on drug development or a related life science field — and have a proven track record of in vitro and in vivo drug metabolism and pharmacokinetic studies. Applicants should possess excellent skills in quantifying novel drug molecules in serum/plasma or tissues and demonstrate solid knowledge in quantitative method development and data interpretation. Candidates with advanced knowledge and skills in high-performance liquid chromatography, mass spectrometry, in vitro ADME and PK studies, and computational modeling will receive preferential consideration.
The selected candidate should possess strong oral and written communication skills and excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner. The selected candidate will be expected to demonstrate a proven ability to collaborate with colleagues to achieve project, team and organizational goals.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter describing your interest in the position, including a career synopsis (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Xin Xu, Ph.D., at xin.xu3@nih.gov. The review of applications will begin on May 15, 2023, and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (i.e., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
3-D Tissue Bioprinting Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (biomedical engineer) position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. The selected candidate must have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology and fluorescence microscopy, as well as experience working with primary cells or induced pluripotent stem cell-derived cells.
The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies, such as scRNA-seq — to develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including the architectural and physiological validation of tissues. Effective communication and presentation skills are required. The selected candidate will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed. The selected candidate must be eligible to work in the United States with NCATS collaborators worldwide.
Applicants to this postdoctoral position must possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in such areas as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology, and engineering of cells with biosensors — will be considered favorably.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for two to three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch           
RNA Therapeutics Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral fellow (molecular biologist) position in the RNA Therapeutics Laboratory within its Division of Preclinical Innovation in Rockville, Maryland. As a member of a dynamic, dedicated and multidisciplinary team of researchers committed to developing therapies for rare disorders, the selected candidate will work on innovative drug discovery projects to develop antisense oligonucleotide (ASO) therapies that can benefit patients and families affected by rare diseases.
The selected candidate will be responsible for designing and developing 2-D and organoid assays to predict various types of toxicity (e.g., neurotoxicity, hepatotoxicity) associated with ASO therapies. The fellow will design and conduct experiments, analyze data, write reports and present research findings at scientific meetings and in peer-reviewed publications. The selected candidate also will collaborate with other members of the research team, as well as external partners, to advance the goals of the RNA Therapeutics Laboratory.
Applicants should have (or expect to receive) a Ph.D. in biochemistry, molecular biology or a related field at the time of joining the laboratory. The ideal candidate should be self-motivated, collaborative and team-orientated, with a strong work ethic and keen attention to detail. The candidate should possess strong oral and written communication skills and a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Bryan J. Traynor, M.D., Ph.D., at traynorb@mail.nih.gov.
The review of applications will begin immediately and continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch           
Medicinal Chemistry Group           
Rockville, Maryland
NCATS, a major research component of NIH, seeks a highly motivated synthetic chemist to serve as a postdoctoral fellow in the Therapeutic Development Branch (TDB) within its Division of Preclinical Innovation (DPI) in Rockville, Maryland. The selected candidate will work on drug discovery projects as part of a multidisciplinary team to identify clinical candidates to address unmet medical needs.
The postdoctoral fellow will be responsible for designing and synthesizing compounds for structure–activity relationship and structure–property relationship studies, developing new technologies to accelerate drug discovery, presenting results in internal and external meetings, and writing reports and manuscripts. Research will be conducted in the TDB medicinal chemistry group.
Applicants should have (or expect to receive) a Ph.D. in organic or medicinal chemistry at the time of joining the laboratory. The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail and be able to work on multiple projects simultaneously. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Wenwei Huang, Ph.D., at huangwe@mail.nih.gov.The review of applications will begin immediately and will continue until the position is filled. .
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Toxicology in the 21st Century (Tox21) Program           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral fellow position in the Toxicology in the 21st Century (Tox21) program within its Division of Preclinical Innovation. To meet the challenges of toxicology research in the 21st century, NCATS has partnered with the National Toxicology Program, the U.S. Food and Drug Administration and the U.S. Environmental Protection Agency to form the Tox21 program. Since 2010, this program has utilized a quantitative high-throughput screening approach to assess a 10,000-compound (10K) library using a group of biologically and toxicologically relevant in vitro assays. The data generated from the screening will be used to prioritize chemicals for further in-depth toxicological evaluation, identify mechanisms of chemical toxicity and develop predictive models for in vivo biological response in humans.
The selected postdoctoral fellow should be self-motivated and prepared to work on Tox21 research projects to develop physiologically relevant assays for assessment of environmental chemicals. NCATS provides a unique and exciting environment that employs state-of-art technologies enabling assay development, chemical screening and profiling for toxicology research.
The postdoctoral candidate will develop in vitro cell-based assays using physiologically relevant cell models (primary cells, stem cell/ induced pluripotent stem cell-derived cells, and 3-D cell/organoid models) with biotransformation-capability for screening chemicals. The fellow will apply new technologies including 3-D cell/organoid models and high-content phenotypic profiling using cell-based imaging assays for evaluating chemical toxicity. The fellow will perform follow-up studies (e.g., mechanisms of compound action) after the primary screening. The fellow also will interact regularly with informatics scientists to aid data analysis and interpretation.
Applicants should hold a doctoral degree (M.D., Ph.D. or equivalent) in the life sciences (e.g., toxicology, pharmacology, biology, cell biology, biochemistry or a related field is preferred) with solid  understanding of toxicology, cell biology or general aspects of signal transduction. A strong preference will be given to applicants with prior experience in in assay development, including biotransformation-capable assays, imaging technology or compound screening. He or she should possess data analysis skills and familiarity with Excel spreadsheets. The applicant must possess strong oral and written communication skills, with a proven publication record in peer-reviewed journals. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to Menghang Xia, Ph.D. at mxia@mail.nih.gov. Applicants also should indicate when they are available to start.
The review of applications review will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Early Translation Branch           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.
The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment within the ETB. He or she will use cutting-edge cell biology and bioassay technologies to develop disease-relevant screening assays and will be involved in all aspects of implementing small molecule screening programs, including assay design, assay development and optimization, high-throughput screening, data analysis, and mechanism-of-action studies to develop assay technologies and novel pharmacological probes.
The postdoctoral candidate will need to have training in drug screening. This project includes the study of a new platinum agent for clinical development, along with an ambitious goal of screening and discovering new uses for platinum chemotherapeutic agents. The trainee will bring experience in cell biology or bioinorganic chemistry and learn to work in a team-based world-class drug discovery environment. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.
Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, bioinorganic chemistry, pharmacology, or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply; prior high-throughput screening experience is not a prerequisite. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATS ETB Careers at ncatsetbcareers@mail.nih.gov. Applicants also should indicate when they are available to start. Please note that the starting date of the fellowship is flexible, preferably within 2023.
The review of applications review will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Early Translation Branch           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral position in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.
The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment within the ETB. He or she will use cutting-edge cell biology and bioassay technologies to develop disease-relevant screening assays and will be involved in all aspects of implementing small molecule screening programs, including assay design, assay development and optimization, high-throughput screening, data analysis, and mechanism-of-action studies to develop assay technologies and novel pharmacological probes.
The postdoctoral candidate will work on a project that includes the study of an understudied target class of enzymes, with the goal of SAR profiling the target class to promote probe development. Successful candidates will have a background in biochemistry, molecular biology, or cellular biology. Enzymology experience is preferred. Experience with drug screening and informatics are useful, but not required. The trainee will learn to work in a team-based world-class drug discovery environment. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she also will draft technical reports and manuscripts and will present their work internally and to external collaborators as needed.
Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, biochemistry, or a related discipline. Applicants interested in furthering their knowledge and exposure to translational science are encouraged to apply; prior high-throughput screening experience is not a prerequisite. The selected candidate should be an independent thinker and a team player who is able to work in an interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter describing your research and career goals, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATS ETB Careers at ncatsetbcareers@mail.nih.gov. Applicants also should indicate when they are available to start. Please note that the starting date of the fellowship is flexible, preferably within 2023.
The review of applications review will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Drug Metabolism and Pharmacokinetics Core           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional scientists to serve as a postdoctoral fellow in bioanalytic assay development for therapeutical biologics — for preclinical development projects involving drug metabolism and pharmacokinetics (DMPK) — within the center’s Division of Preclinical Innovation.
The DMPK Core partners with collaborators (academic institutions, foundations and private industry) to conduct preclinical discovery and development studies leading to Investigational New Drug (IND) applications for new therapeutics. These projects play a leading role in NCATS’ mission to develop new ways to reduce, remove or bypass bottlenecks across the entire continuum of translational science and to address rare and neglected diseases.
The selected candidate will collaborate with team members to evaluate, develop and implement bioanalytical assays to quantify therapeutical biologics and its carriers in blood and tissues for assigned projects. Specific duties include providing bioanalytical strategies for novel therapeutical biologics, such as peptides, conjugated peptides, monoclonal antibodies, engineered human proteins, antibody-drug conjugates, oligonucleotides, mRNAs, gene therapies and other novel modalities. The selected candidate also will be responsible for generating specific reagents for the assay development and will collaborate with biologists and researchers across different teams within NCATS to address project-specific needs. Additional duties include quantitatively analyzing biological samples collected from preclinical pharmacokinetic and biodistribution studies, preparing documents for the regulatory filing purpose, and disseminating research via peer-reviewed publications and participating in scientific conferences and meetings.
The selected candidate should possess strong oral and written communication skills and excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner. The selected candidate will be expected to demonstrate a proven ability to collaborate with colleagues to achieve project, team and organizational goals.
Applicants to this postdoctoral fellow position should hold a Ph.D. in biology, immunology, biochemistry, analytical chemistry, proteomics, pharmaceutical science or a related field and have a proven track record of quantitative bioanalytical method development (e.g., ligand binding assays); excellent skills to quantify active biologics in serum/plasma or tissues; and a solid knowledge in method validation and data interpretation. Candidates with advanced knowledge and skills in high-performance liquid chromatography, mass spectrometers, electrochemiluminescence ligand binding device  or related instruments will receive preferential consideration. Applicants with experience working on qPCR, TR-PCR, proteomics sample preparation and immunogenicity assessment will be considered favorably. Candidates also should have strong oral and written English communication skills and be able to work in a highly collaborative team setting.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please email a cover letter describing your interest in the position, including a career synopsis (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Xin Xu, Ph.D., at xin.xu3@nih.gov. The review of applications will begin on July 1, 2022, and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Computational Toxicology Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a computational toxicology/informatics postdoctoral position in the Computational Toxicology Laboratory within the center’s Division of Preclinical Innovation (DPI). To meet the challenges of toxicology research in the 21st century, NCATS has formed a partnership  with the National Toxicology Program, the U.S. Food and Drug Administration, and the U.S. Environmental Protection Agency to develop a high-throughput screening (HTS) program. The goals of the Toxicology in the 21st Century (Tox21) program are to prioritize chemicals for further in-depth toxicological evaluation, identify mechanisms of chemical toxicity and develop predictive models for in vivo biological response in humans. NCATS has a unique and exciting environment that employs state-of-art technologies for assay development, chemical screening and profiling for toxicology research.
The selected candidate will engage in several activities, including analyzing large data sets generated from HTS assays; developing novel methods to identify and prioritize toxicity response pathways for assay development and compound testing; building predictive models for different in vivo toxicity endpoints using chemical structural data, genomic data and in vitro assay data; and generating testable hypotheses on compound mechanisms of toxicity. The candidate should be familiar with public genomic and genetic databases and be capable of data mining using complex data sets. The successful candidate also should have experience building and integrating genomic databases and working at the interface of genomic and chemoinformatic information. The fellow will work closely with informatics scientists and biologists in the DPI to aid in data interpretation and project development.
Applicants to this position should possess a Ph.D. in the biomedical sciences, extensive experience with one or more programming languages, and knowledge in database queries and data retrieval. A background in cheminformatics or bioinformatics, biology, chemistry or toxicology is preferred. Experience in 2-D or 3-D modeling, large data set manipulation or data mining is a plus. The ideal candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit (via email) a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Ruili Huang, Ph.D., at huangru@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
3-D Tissue Bioprinting Laboratory           
Rockville, Maryland
NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill neuroscientist postdoctoral fellow positions in the Division’s 3-D Tissue Bioprinting Laboratory. The selected candidates will develop human functional neural 3-D tissue models as assay platforms for the discovery and development of new therapeutics for pain, addiction or overdose. Applicants with a background in neurosciences, in vitro neural organotypic models and neural stem cells will receive preferential consideration.
The selected candidates will work as part of a multidisciplinary team of innovative scientists with expertise in bioengineering, 3-D bioprinting, quantitative cell imaging, electrophysiology, histology, assay development, drug screening, data science and other cutting-edge “omics” technologies. The selected candidates will develop and characterize functional 3-D neural organotypic assays for drug discovery and development.
Applicants to these postdoctoral fellow positions should possess a Ph.D. in neuroscience, cell biology, molecular biology, pharmacology, pathology or a related discipline with relevant experience in neuroscience, physiology and pathology of the nervous system to help establish a portfolio of assays to model neural circuitry of pain, addiction and overdose. The ideal candidates will be expected to work independently as well-trained problem solvers in the production of 3-D neural organotypic models, including architectural and physiological validation, and develop functional assay readouts for drug screening. They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.
Experience in techniques necessary to develop CNS and PNS assays for drug testing using tissues, including extracellular electrophysiological recording (field potential or multi-unit), calcium imaging, neural stem cell and primary cell culture and associated analysis is required. Experience with techniques such as histology, quantitative analysis of microscopy images, time-lapse microscopy is highly desired. Candidates with additional experience in physiology and pathology of pain, addiction or overdose, optogenetics microscopy, or tissue engineering or bioprinting techniques will receive preferential consideration. Each candidate should be an independent thinker and team player able to work and multitask in a highly interactive, fast-paced environment. The ideal candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit (via email) a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information of at least three references to NCATSbioprinting@mail.nih.gov.
The review of applications will begin immediately and will continue until these positions are filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Informatics Core           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral bioinformatics position in the Informatics Core (IFX) within the Division of Preclinical Innovation.           

The IFX is an interdisciplinary team of bioinformaticians, clinical informaticians, cheminformaticians and software engineers who collaborate closely with molecular biologists to augment the use of metabolomics and multi-omics analysis approaches to identify dysregulated pathways and putative therapeutic targets.
The selected candidate — a postdoctoral fellow in bioinformatics — will have a solid foundation in bioinformatics and biostatistics, including machine learning, and experience in cleaning, processing, and integrating metabolomic and other -omic datasets. He or she will develop novel bioinformatics methods to optimize the predictive capacity of metabolomics and -omic (e.g., proteomic, transcriptomic) profiles in differentiating groups (e.g., cell characteristics, individuals). These novel approaches will augment the bioinformatics field by addressing issues not addressed by standard approaches. The selected candidate will interact closely with computational and noncomputational (e.g., biologists, chemists, clinicians) IFX and NCATS scientists and our academic collaborators. In addition to working independently on collaborative translational research projects, the fellow also would be involved in building a computational infrastructure for the QC, analysis and interpretation of metabolomic and multi-omic profiles. He or she will be expected to draft manuscripts and publish results in high-impact, peer-reviewed scientific journals and to present results at internal and external scientific meetings.
The ideal candidate should possess a doctoral degree or equivalent in bioinformatics, biomedical informatics, or a related field and have demonstrated hands-on experience in leading the large-scale analysis of multi-omic data. Experience with metabolomics data is strongly preferred. He or she should have demonstrated experience leveraging publicly available datasets, including their organization, cleaning and preprocessing. Applicants also should have demonstrated experience in multivariable analyses and machine/deep learning. Basic knowledge and understanding of biology and chemistry is a plus. Knowledge of R and/or Python and working within a high-performance computing/cloud environment is required.           

The selected candidate should have excellent interpersonal, verbal and written communication skills in English and should possess strong collaborative, organizational and recordkeeping skills; the ability to work productively as a member of a diverse and dynamic multidisciplinary team, managing multiple research studies simultaneously; and the desire to acquire new skills as required for research studies. While the team is highly collaborative in nature, the pursuit of original computational research directions by the candidate is encouraged. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit (via email) a cover letter describing your career goals and interest in the position, including a research summary (one to two pages), a current curriculum vitae with a complete bibliography, and the names of and contact information for at least three references to Ewy A. Mathé, Ph.D., at ewy.mathe@nih.gov.           

The review of applications will begin immediately and will continue until the position is filled. Learn more about informatics research at NCATS.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
3-D Tissue Bioprinting Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral biomedical engineering position in the 3-D Tissue Bioprinting Laboratory within its Division of Preclinical Innovation. The selected candidate should have expertise in tissue biofabrication to help establish a portfolio of complex physiologically relevant 3-D tissue models as predictive screening platforms to study viral infections and conduct drug testing. Applicants should have additional expertise in histology, fluorescence microscopy and experience working with primary cells or induced pluripotent stem cell-derived cells.
The selected candidate will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies — including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other -omics technologies including scRNAseq — to develop advanced cellular models for drug discovery and development. The selected candidate should be a self-motivated, driven, thorough and careful experimentalist with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced team environment. They also will be expected to work independently as well-trained problem solvers in tissue biofabrication, including architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The selected applicants will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and present work to internal and external collaborators as needed. The selected candidates also should be eligible to work in the U.S. with whomever NCATS collaborates worldwide.
Each applicant to this postdoctoral position should possess a Ph.D. in bioengineering or biomedical engineering. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays — including work in areas such as organoids, tissue chip or biofabricated tissues, biomaterials, cell imaging, histology and engineering of cells with biosensors — will be considered favorably.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for two to three references, including your current supervisor, to NCATSbioprinting@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Early Translation Branch           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to hold a postdoctoral position in antibody discovery and characterization in the Early Translation Branch (ETB) of its Division of Preclinical Innovation. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.
The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment and be exposed to cutting-edge high-throughput screening, assay biology, bioinformatics, medicinal chemistry and disease-relevant biological models. They will implement antibody discovery technologies (including phage display), directed evolution, and related technologies to produce and characterize antibodies relevant to diseases and conditions related to pain, addiction and overdose, and other public health emergencies, such as the SARS-CoV-2 pandemic. The selected applicant will apply cutting-edge cell biology and bioassay technologies for the development of disease-relevant antibody selection and screening assays and will be involved in all aspects of the implementation, including assay design, assay development and optimization, antibody screening, protein engineering, data analysis and mechanism-of-action studies.
The selected candidate should be able to work independently under team supervision. The selected applicant will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports and manuscripts and will present work internally and to external collaborators as needed.
Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, pharmacology or a related discipline. Experience with antibody phage display technologies — including panning, ELISA, and protein purification — and an understanding of antibody domain architecture are highly desirable. The candidate should be an independent thinker, a team player, and able to work in a very interactive, fast-paced environment. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSantibody_hiring@nih.gov. Selected applicants will be required to submit letters of reference to complete the hiring process.
The review of applications will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch           
Rockville, Maryland
NCATS, a major research component of NIH, seeks a highly motivated synthetic chemist to serve as a postdoctoral fellow for drug discovery projects within the Therapeutic Development Branch (TDB) of its Division of Preclinical Innovation. The selected candidate will work on a multidisciplinary team to identify clinical candidates to address unmet medical needs.
The postdoctoral fellow will be responsible for designing and synthesizing compounds for structure-activity relationship and structure-property relationship studies, developing new technologies to accelerate drug discovery, presenting results in internal and external meetings, and writing reports and manuscripts. The research will be conducted in the TDB medicinal chemistry group.
Applicants should have (or expect to receive) a Ph.D. in organic chemistry or medicinal chemistry at the time of joining the laboratory. The ideal candidate should be self-motivated, possess a strong work ethic, have keen attention to detail, and be able to work on multiple projects simultaneously. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit a cover letter describing your interest in the position, including a research summary, a current curriculum vitae, and the names of and contact information for three references to Wenwei Huang, Ph.D., at huangwe@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled. 
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Genomic Toxicology Laboratory           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral position and apply genomic tools to toxicology and pharmacology in the Genomic Toxicology Laboratory within the center’s Division of Preclinical Innovation (DPI). The Genomic Toxicology Laboratory, led by David L. Gerhold, Ph.D., participates in the Toxicology in the 21st Century (Tox21) program by developing methods to assess the effects of chemicals on human health, focusing on early stages of the translational process from target validation to first-in-human studies. This laboratory also develops novel human cellular 3-D and co-culture models to study cardiovascular disease, as well as neurological and renal diseases. DPI researchers collaborate closely with scientists in the 3-D Tissue Bioprinting Program, the Stem Cell Translational Laboratory, and the Therapeutics for Rare and Neglected Diseases program, as well as with other NIH institutes, centers and offices; and academic scientists. In addition to conducting cutting-edge laboratory research, DPI scientists work in a team-based environment and collaborate with more than 250 research organizations worldwide.
The selected candidate — a self-motivated, collaborative postdoctoral fellow — will complete the development and implementation of a novel high-throughput screening method that quantifies the expression of selected genes in cultured mammalian cells. The unprecedented throughput of this method will enable the screening of large chemical libraries of environmental toxicants or drug candidates. Because quantitative high-throughput screening of large chemical libraries is NCATS’ core expertise, the collaborative opportunities to apply this method to identify drug candidates and to screen Tox21 toxicant libraries are abundant. The successful applicant will work with collaborators who have developed induced Pluripotent Stem Cell (iPSC)–derived endothelial cells, as well as 3-D endothelial cell models that incorporate shear flow and co-culture with vascular smooth muscle cells. The postdoctoral candidate also will have opportunities to collaborate with scientists both within and outside of NCATS on additional projects. The selected candidate is expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals.
The ideal candidate will possess a doctoral degree (i.e., a Ph.D.) with a background in a relevant field of molecular or medical biology and have a strong record of high-impact publications. Applicants should possess molecular biology expertise and mammalian cell culture skills. Applicants also should possess strong oral and written English communication skills. Applicants with additional expertise in vascular biology or high-throughput screening will receive preferential consideration.
Applicants should be U.S. citizens or legal residents or should hold a valid work permit to be considered for the position.
Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to David L. Gerhold, Ph.D., at NCATSGenomicTox@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Analytical Chemistry Core Facility           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation. The selected candidate should have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.
The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.
The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.
The successful applicant should possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a preferred. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable.
The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate should possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants should be eligible to work in the United States for any employer.
Please submit a cover letter describing your interest in the position, including a research summary (one to two pages); a current curriculum vitae with a complete bibliography; and the names of and contact information for at least three references to Christopher A. LeClair, Ph.D., at ncats_info@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
3-D Tissue Bioprinting Laboratory           
Rockville, Maryland
NCATS’ Division of Preclinical Innovation seeks applications from qualified candidates to fill postdoctoral bioengineering positions in the Division’s 3-D Tissue Bioprinting Laboratory. The selected candidates should have expertise in biofabrication, biomaterials or microfluidics to help establish a portfolio of functional, physiologically complex 3-D tissue models as predictive screening platforms for toxicity and efficacy drug testing. Applicants with additional expertise in microphysiological systems, immunology, neuroscience and production of induced pluripotent stem cell-derived cells will receive preferential consideration.
The candidates will work as part of a multidisciplinary team of innovative scientists, using cutting-edge biofabrication methodologies—including 3-D bioprinting, quantitative cell imaging, histology, assay development, drug screening, data science and other cutting-edge -omics technologies — to develop advanced cellular models for drug discovery and development. Candidates should be self-motivated, driven, thorough and careful experimentalists with the ability to multitask, think independently and work in a highly creative, interactive and fast-paced environment. They also will be expected to work independently as well-trained problem solvers in biofabrication and microfluidics, including on architectural and physiological validation of the tissues. Effective communication and presentation skills are required. The successful candidates will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports, manuscripts and patent applications and will present work to internal and external collaborators as needed.
Each applicant for this postdoctoral position should possess a Ph.D. in bioengineering, biomedical engineering, immunology, neuroscience, cell/molecular biology, pharmacology, pathology or a related discipline relevant to 3-D tissue models. Candidates with previous experience developing and characterizing complex 3-D cell-based functional assays—including work in such areas as organoids or biofabricated tissues, biomaterials, microfluidic systems, cell imaging, histology and engineering of cells with biosensors—as well as experience using bioprinting techniques, will be considered favorably. Candidates with a strong background in immunology and tissue engineering with induced pluripotent stem cell-derived cells are encouraged to apply. Applicants should be eligible to work in the United States for any employer.
Please submit a cover letter, a curriculum vitae with a complete bibliography, a one-page research proposal/plan for a physiologically complex 3-D tissues for disease modeling and compound testing, and the contact information for at least three references to NCATSbioprinting@mail.nih.gov.
The review of applications will begin immediately and will continue until these positions are filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Therapeutic Development Branch           
Rockville, Maryland
NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral computational biologist/bioinformatician position in NCATS’ Therapeutic Development Branch (TDB) within the Division of Preclinical Innovation.
TDB develops new systems, novel approaches and methodologies to achieve conceptual breakthroughs in preclinical therapeutics. The branch also provides collaborative access to technology and expertise in the scientific disciplines of early-discovery biology and medicinal chemistry; drug metabolism and pharmacokinetics; toxicology; and chemistry, manufacturing and controls synthesis and formulation.
The selected candidate — a self-motivated, collaborative postdoctoral fellow — will join an interdisciplinary team with a focus on profiling different cell types and responses in the context of rare genetic diseases, infectious diseases and drug treatments. He or she will be a bioinformatician/computational biologist with experience in bioinformatic analysis of NexGen sequencing datasets, with a strong emphasis in RNA-Seq analysis (bulk and single-cell). The fellow will collaborate with researchers in other universities and institutes and will learn preclinical drug development from colleagues in multidisciplinary project teams. The fellow should obtain extensive experience and skills in this training program that can be applied toward translational research for therapeutics development.
The ideal candidate should possess a doctoral degree or equivalent in biology, computer sciences, bioinformatics or a related discipline, with one to three years of relevant research experience. Candidates should possess strong computer programming skills in R and other required languages (e.g., Python/Perl, Java, C/C++). Experience analyzing bulk and single-cell RNA-Seq data sets is essential. The candidate also should possess strong self-motivational and problem-solving skills, as well as outstanding interpersonal and teamwork skills. Excellent analytical, organizational and time management skills are required. Experience with proteomics data sets also is preferred, but not necessary. Applicants should be eligible to work in the United States for any employer.
Please submit a cover letter describing your interest in the position; a current curriculum vitae with a complete bibliography; and the names of and contact information for three references to Wei Zheng, Ph.D., at NCATSTDBBioHiring@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
NCATS Chemical Genomics Center (NCGC), Adenine Informatics Group           
Rockville, Maryland
NCATS is one of the 27 institutes and centers at NIH. The Informatics group collaborates closely with biologists and chemists to develop robust assay designs, analyze experimental outcomes and validate new hypothesis. NCATS’ informatics personnel perform a variety of ligand- and protein structure-related modeling tasks, support the drug discovery process and accelerate translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.
NCATS’ Informatics group seeks a creative, self-motivated postdoctoral informatics scientist to develop new algorithms for prediction of i) protein-ligand interactions; ii) chemical reactions and comprehensive support of drug discovery projects.
The postdoctoral fellow will be responsible for uploading and analyzing pilot and quantitative high-throughput screening runs; analyzing assay reproducibility; analyzing confirmation and secondary screening assays; developing and applying QSAR models and molecular modeling for virtual screening of compounds; supporting medicinal chemistry efforts; and developing new algorithms for prediction of protein-ligand interactions and chemical reactions. Research will be conducted by NCATS’ Informatics group.
The ideal candidate will possess a minimum of a Ph.D. in computational science/bioinformatics with specialization in machine learning. He or she will have published at least three research articles as first author. The successful candidate should have experience with common cheminformatics libraries and data formats (e.g., RDKit, OpenBabel, SMILES, InChi, etc.), modern software packages (e.g., MOE/CCG, OpenEye tools) and scientific programming (e.g., Python, JAVA) and data analytics (e.g., KNIME, Spotfire). He or she should be able to script work flows and implement new algorithms, have experience working with multi-disciplinary teams, and possess strong oral and written English communication skills. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras), as well as experience in developing algorithms for prediction of protein-ligand interactions and/or chemical reactions.
Applicants should be U.S. citizens or legal residents or should hold a valid work permit to be considered for the position.
Please submit a cover letter describing your interest in this position, a current curriculum vitae with a complete bibliography to Alexey V. Zakharov, Ph.D., at alexey.zakharov@nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Informatics Group           
Rockville, Maryland
NCATS’ Informatics group seeks a creative, self-motivated, collaborative research scientist to develop new algorithms for predicting chemical reactions and to provide comprehensive support of the center’s A Specialized Platform for Innovative Research Exploration (ASPIRE) initiative.
NCATS proposes to transform chemistry from an individualized craft to a modern, information-based science through ASPIRE. By addressing long-standing challenges in the field of chemistry — including lack of standardization, low reproducibility and an inability to predict how new chemicals will behave — ASPIRE is designed to bring novel, safe and effective treatments to more patients more quickly at lower cost.
The Informatics group collaborates closely with biologists, chemists, engineers and information technology professionals to develop robust assay designs, analyze experimental outcomes and to validate new hypothesis. NCATS’ Informatics group performs a variety of ligand- and protein structure-related modeling tasks, supports the drug discovery process and accelerates translational sciences. The team members also are developing infrastructure and software for the meta-analysis of high-content screens and for integration of the existing biomedical data to discover new hypothesis.
The successful candidate will be an integral team member for the creation and maintenance of a chemical reaction database, the development of new methods for reaction normalization and standardization, the analysis of reaction screens, and the development and application of AI/Machine learning approaches for prediction of synthetic routes and chemical reactions. He or she also should have experience working with multi-disciplinary teams.
Applicants should possess a minimum of a Ph.D. in computational chemistry or a related field with one to three years of industry or academic experience. He or she should have experience using modern machine learning and deep learning frameworks (e.g., TensorFlow, Keras, sklearn, PyTorch, etc.) Applicants also should have experience with common cheminformatics libraries and data formats (e.g., RDKit, Indigo, CDK, SMIRKS, SMARTS, SMILES, InChi, etc.), as well as experience in scientific programming (e.g., Python, JAVA), data analytics (e.g., KNIME, Spotfire) and relational databases (e.g., Oracle, SQL). Additionally, applicants should be able to script work flows and implement new algorithms. Applicants also should possess strong oral and written English communication skills.
Please submit a cover letter describing your interest in this position, a current curriculum vitae with a complete bibliography (all in PDF format), and three letters of reference to Alexey V. Zakharov, Ph.D., at NCATSAspire-Hires@nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
National Institutes of Health           
National Center for Advancing Translational Sciences           
Division of Preclinical Innovation           
Chemical Genomics Branch           
Stem Cell Translation Laboratory           
Rockville, Maryland
NCATS, a major research component of the NIH, seeks applications from qualified candidates with expertise in developmental biology and human induced pluripotent stem cells (iPSCs) to fill stem cell scientist and postdoctoral positions in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as iPSCs, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D and 3-D cell culture systems. Successful candidates will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS, external service providers and collaborators at top academic institutions.
The selected candidates will join a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, compound management, automation engineering, bioinformatics, medicinal chemistry and various -omics technologies. They will work in a highly creative environment, focusing on important aspects of human pluripotency and cellular differentiation using cutting-edge technologies (e.g., single-cell analysis, deep sequencing, robotic cell culture, high-throughput electrophysiology, genome editing). They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.
Each applicant should possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Exceptional candidates with master’s degrees and strong backgrounds in stem cell biology will be considered. Candidates with experience in drug discovery, cell and tissue engineering, cell signaling, or quantitative biology are encouraged to apply. The ideal candidates should be team players with high scientific standards and have the ability to work in an interactive, fast-paced environment. They should be self-motivated to learn new technologies and be familiar with the methods and concepts of stem cell biology and regenerative medicine.
Annual stipends are commensurate with experience and based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The fellow also may participate in Foundation for Advanced Education in the Sciences courses at NIH. The position is renewable for up to 5 years.
Please submit a cover letter describing your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.
The review of applications will begin immediately and will continue until the position is filled.
Employment is subject to the successful completion of the preappointment process (e.g., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents).
At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.
For language access assistance, contact the NCATS Public Information Officer
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